Jonathan Stewart vs. Kansas City

Stewart still splits time with DeAngelo Williams, but he's become the power option for John Fox's squad, particularly in the red zone. Here's a great spot for a breakthrough effort, playing at home against a run defense that surrenders 176.5 yards per game. With Jake Delhomme and the passing game starting to click, the Kansas City defense will be on its heels.

Brandon Jacobs vs. Seattle

Jacobs and the Giants come out of the bye week rested and determined to put forth a four-quarter effort at home. Seattle's run defense has been strong against the trio of Lynch, Gore and Jackson, but Jacobs represents a different type of challenge. He may not pile up a mountain of yards. However, I do expect him to find the end zone.

Reggie Bush vs. Minnesota

This is a difficult matchup, without question. Bush hits this list because I suspect we see him more as a receiver. Deuce McAllister's ready to handle the workload between the tackles, but it'll be rough going. Bush's value will be in the receiving game, as defenses will now have to respect Lance Moore following last week's breakout effort.

Ryan Grant vs. Atlanta

Grant owners continue to seek that breakout game and signs his 2007 season wasn't an aberration. I wasn't convinced he'd match his 2007 form. In fact, in my preseason predictions column, written just ahead of the opening kickoffs, I stated he'd just narrowly top his second-half heroics despite a 16-game slate. This is a good spot for him, though. He'll likely figure more prominently into the early play-calling if Matt Flynn's under center. Atlanta surrenders 131.3 rushing yards per game.

Ronnie Brown vs. San Diego

What can Brown do for an encore? We can be fairly certain he won't run for another four touchdowns. However, I do anticipate the Brown-Ricky Williams combination fares better than the four previous opponents on the ground. Remember, previous opponents have launched aerial assaults, thereby reducing the impact of their respective running games. I'm still calling for 120-130 total yards and a touchdown.

Running Back Sleeper Candidates

Mewelde Moore at Jacksonville

Moore's the last man standing for the Steelers this week. Like everyone else, he struggled on the ground against the Ravens (eight carries for 13 yards), but he demonstrated great elusiveness as a receiver out of the backfield (three receptions for 37 yards). Jacksonville's allowing 101.4 yards and a rushing touchdown per game. I believe Moore's true value will be as a receiver, operating in space and thereby generating more time for Ben Roethlisberger in the downfield passing game.

Laurence Maroney at San Francisco

The 49ers have been run over through four weeks, surrendering 124.5 rushing yards per game. Maroney didn't appear on the injury report early this week (does that matter?) and will assume the lead role in the New England backfield this weekend. He's only rushed for 67 yards this year and will undoubtedly cede some carries to LaMont Jordan, but I'm optimistic we see some of that talent that made him an early-second round fantasy pick in 2007. The Pats have been counted out by many. Getting called out by Al Davis probably stoked Bill Belichick's fire this week.

Warrick Dunn at Denver

Opponents have been positively crushing the Broncos' run defense through four weeks, averaging 132.8 yards per game. I offer Dunn as an option for fantasy owners in deeper leagues this weekend. He's averaged 10.5 rushing attempts per game, and I suspect he and Earnest Graham play a significant role this weekend. The Brian Griese-led passing attack's been intriguing, but he's turned the ball over too many times. Look for Gruden to restore balance this week and get the ball into his running backs' hands.

Running Back Flop Candidates

Edgerrin James vs. Buffalo

James was a non-factor in the yardage column last week after the Jets jumped out to a huge lead. However, he did get a chance to finish off drives with two goal-line chances and scored twice. This is a difficult matchup against the Buffalo defense, and I suspect we see more of Tim Hightower to help open space downfield for Kurt Warner to operate. James averaged 82.7 rushing yards in the Cardinals' first three games, and I suspect he approaches that mark this week. Just look for the rookie to vulture the goal-line opportunities in a tighter game.

Maurice Jones-Drew and Fred Taylor vs. Pittsburgh

The Jaguars' running backs have produced one good game between them in 2008. Both Jones-Drew and Taylor topped 100 rushing yards in Week 3. They haven't cracked 50 rushing yards in any of the team's other three contests. The Steelers rank fourth in run defense at 74 yards per game. Pittsburgh will be without run-stuffer Casey Hampton, so perhaps there's some hope, but don't get over-optimistic given Jacksonville's O-Line woes.

Chris Johnson and LenDale White at Baltimore

The Ravens have yet to surrender a rushing touchdown while allowing fewer than 70 yards per game. This game looks to be another smash-mouth contest similar to last week's tilts between Baltimore and Pittsburgh and the Titans' own battle with Minnesota. Look for smallish yardage totals and perhaps a short score from each off of turnovers.

Top 10 Wide Receivers (exclude Larry Fitzgerald, Anquan Boldin, Brandon Marshall, Randy Moss, Wes Welker, T.J. Houshmandzadeh, Andre Johnson, Greg Jennings, Steve Smith and Terrell Owens)

Calvin Johnson vs. Chicago

Johnson opened the season with two monster games, and was then somewhat of a bystander in the blowout loss to San Francisco. With the cloud of Matt Millen no longer overhead, perhaps this team gets back to work and just plays football. I expect the Lions to be ready to play at home against the division rival Bears. Johnson's tough to matchup with in single coverage, and the Bears will need to give first-time starter Corey Graham help against Roy Williams.

Santana Moss at Philadelphia

Moss is clearly past the injuries that slowed his game in 2007, and his timing with Jason Campbell's been impeccable. He's being targeted nearly 11 times per game, and though he faces a tough individual matchup, I believe he'll post another big game. The Eagles will cinch up to stop Clinton Portis, and the quick hits from Campbell have the potential to turn into big plays. Moss has already caught 27 passes this season.

Chad Ocho Cinco at Dallas

Ocho Cinco's already called his shot. He's anticipating giving the Texas star a smooch at midfield. Whether he gets to follow through on that promise remains to be seen. However, we do know that Ryan Fitzpatrick (assume Palmer's out for the moment) will be forced to throw in order to play catch-up with the vaunted Dallas offense. Ocho Cinco scored his first touchdown of 2008 last week, and I expect him to find the painted grass again this weekend. What happens from there is anybody's guess.

Lance Moore vs. Minnesota

Moore was the breakout star of Week 4 with his seven-reception, two-touchdown game against San Francisco. I expect more of the same this weekend (OK, just one touchdown this time around). The Vikings will work to slow Deuce McAllister's comeback effort, but you can't stop Drew Brees. If afforded time to throw, he'll find his spots. Moore remains the top option for several more weeks.

Lee Evans at Arizona

Evans made a rare early-season end zone appearance in Week 4 against the Rams last weekend. Can he make it two straight? I believe it's entirely possible. The Cardinals will play without top pass rusher Bertrand Berry, and it's probable Adrian Wilson remains on the shelf. As such, Trent Edwards will take shots downfield, and I expect to see No. 83 running under the deep ball.

Dwayne Bowe at Carolina

The Kansas City offense doesn't get you too excited, I know. You just can't ignore how efficiently Damon Huard plays and how his top receivers continue to make plays. Tony Gonzalez will play a huge role in this game, as the team seeks to silence the chatter following last week's blow-up. That just makes for more opportunities for Bowe, who's averaging 5.5 receptions and nearly 67 receiving yards per game. He's always a prime target in the red zone, and I expect him to notch his third touchdown of the season.

Hines Ward at Jacksonville

Here's the week for Ben Roethlisberger to get on track. He won't face nearly the same type of pressure we've seen for the past several weeks, and this Jacksonville unit has more than a few injured players in tow. Ward's been held without a touchdown in two straight games, as Roethlisberger was constantly under pressure and working to elude fierce pass rushes. This week, he settles into the pocket and re-establishes that connection with Ward, who smiles his way to the end zone.

Roddy White at Green Bay

White continues to be the lone consistent threat for Matt Ryan. Somehow, White continues to find space against press coverage to make plays. Of course, being able to out-run coverage certainly doesn't hurt. Following a slow start, Ryan and White have clicked in the past two weeks (12 receptions for 209 yards and a touchdown). I expect the Falcons to lose this road tilt, as this young team's yet to find any semblance of consistency at home. White's matchup against Charles Woodson is daunting. However, Woodson's banged up (I know he took one to the house last week), and White's a bit more to handle than the resurgent Antonio Bryant. I anticipate White and Ryan continue their long-gain magic. He won't catch many balls, but he'll get the long one to make up for it.

Amani Toomer vs. Seattle

The veteran receiver leads the pack this weekend, as top option Plaxico Burress is out because of the team suspension. Toomer caught a total of 11 passes for 131 yards and a touchdown against the Rams and Bengals. He remains a nice, safe target for Eli Manning, a good route-runner who knows how to settle into a soft space in the defense. He also remains a top red zone option.

DeSean Jackson vs. Washington

Jackson's talent is unmistakable. Now, he just needs to keep his head in the game for 60 minutes. The team's reliance on his play-making ability will be lessened this week now that Reggie Brown's proven his injuries are behind him. I don't believe his overall impact will be decreased in any way. He still possesses the speed and first move to break containment, and he's a threat to make a play on every throw. In fact, Brown's return makes him more dangerous.

Wide Receiver Sleeper Candidates

Steve Breaston vs. Buffalo

Breaston posted a huge statistical day in the ridiculous lopsided loss to the Jets, catching nine passes for 122 yards. Anquan Boldin's questionable for this week with a sinus fracture, which puts Breaston into the No. 2 slot if Boldin should be unavailable. Jerheme Urban should also be on the radar in deeper leagues. He's the possession receiver underneath, with Breaston serving as the deep ball threat. Look for Kurt Warner to take a few shots downfield early to back off the linebackers in Dick Jauron's attacking scheme.

James Jones vs. Atlanta

It remains to be seen whether Aaron Rodgers will be available to the Packers this weekend because of the shoulder injury that limited him to hand-offs on Wednesday. I suspect we see Matt Flynn under center, and that portends to more looks for the secondary and tertiary options in the receiving corps. Jones reclaims his third receiver slot this weekend against an inexperienced and porous Atlanta secondary in front of the home crowd.

Reggie Brown vs. Washington

Brown returned to action and immediately became a fixture on Donovan McNabb's radar. DeSean Jackson's been phenomenal, but a few mental lapses have loomed large for the Eagles (and spiteful fantasy owners). Brown caught six passes for 69 yards in his first action and demonstrated the injuries that sidelined him through the preseason and into the regular season are in his past. I expect to see him take on a larger number of looks from McNabb this weekened.

Roy Williams vs. Chicago

Williams has complained of a smallish role in Detroit, but I suspect his role's been addressed during the team's bye week. He'll face off against Corey Graham, a second-year cornerback who will start in place of injured Nathan Vasher (hand surgery).

Wide Receiver Flop Candidates

Justin Gage at Baltimore

Gage missed Wednesday's workout because of a knee injury, but I'm sliding him into this slot based solely on the matchup. The Baltimore defense had been flying around, and I don't know that I've seen a harder-hitting unit this year (sorry Philly and Tennesse, just ask the Pittsburgh running backs). The Ravens are surrendering just 117 passing yards per game! Gage had a nice return from his groin injury in Week 4, with 92 receiving yards, but I'm just not sure Kerry Collins will have time to operate. He certainly won't be helped by the running game in this one.

Chris Chambers at Miami

Chambers faces off with his old team coming out of its bye week. Might this be the breakout week for fantasy owners? It certainly could, but the fact he's caught only eight passes through four games is mighty disconcerting. The Dolphins currently rank 26th against the pass (226.7 yards and two touchdowns per game), so there's reason to be optimistic for a breakout game. However, with two weeks to prepare for their former teammate and still riding high after containing Randy Moss and the Patriots in Week 3, the Dolphins just might rise up for another big effort at home. Start him as a WR3, but temper your expectations.

Keep your browser locked onto FOXSports.com for all of the latest player and team news as the countdown to kickoff winds down. You can contact me during the "FOX Fantasy Freaks" on FOX Sports Radio on Sunday morning from 10 a.m. - 12 p.m. ET (7-9 a.m. PT).

Good luck!